Hepatocyte-specific inhibition of NF-κB leads to apoptosis after TNF treatment, but not after partial hepatectomy
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چکیده
منابع مشابه
Hepatocyte-specific inhibition of NF-κB leads to apoptosis after TNF treatment, but not after partial hepatectomy
The transcription factor NF-κB has been implicated in both hepatocyte proliferation and apoptosis. Mice deficient in the p65 subunit of NF-κB die during gestation from hepatocyte apoptosis (1). Inhibition of NF-κB in hepatocyte cell lines blocked TNF-induced proliferation and sensitized these cells to apoptosis (2, 3). Furthermore, while inactive in adult, quiescent liver, NF-κB is rapidly acti...
متن کاملHepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy.
One of the earliest TNF-dependent events to occur during liver regeneration is the activation of the transcription factor NF-kappaB through TNF receptor type 1. NF-kappaB activation in the liver can have both antiapoptotic and proliferative effects, but it is unclear which liver cell types, hepatocytes or nonparenchymal cells (NPCs), contribute to these effects. To specifically evaluate the rol...
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Toxins convert the hepatocellular response to tumor necrosis factor-α (TNF-α) stimulation from proliferation to cell death, suggesting that hepatotoxins somehow sensitize hepatocytes to TNF-α toxicity. Because nuclear factor-κB (NF-κB) activation confers resistance to TNF-α cytotoxicity in nonhepatic cells, the possibility that toxin-induced sensitization to TNF-α killing results from inhibitio...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2002
ISSN: 0021-9738
DOI: 10.1172/jci15295